Biodegradable poly(ethylene glycol)-block-poly(-lactic acid) (PEG-b-PLA) nanoparticles\n(NPs) were prepared by nanoprecipitation with controlled dimension and with different electric\ncharges, as monitored by dynamic light scattering (DLS). Then NPs were loaded within hydrogels\n(HG) developed for biomedical applications in the central nervous system, with different pore\nsizes (30 and 90 nm). The characteristics of the resulting composite hydrogel-NPs system were\nfirstly studied in terms of ability to control the release of small steric hindrance drug mimetic.\nThen, diffusion-controlled release of different charged NPs from different entangled hydrogels\nwas studied in vitro and correlated with NPs electric charges and hydrogel mean mesh size.\nThese studies showed different trends, that depend on NPs superficial charge and HG mesh size.\nRelease experiments and diffusion studies, then rationalized by mathematical modeling, allowed us\nto build different drug delivery devices that can satisfy different medical needs.
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